Why Work Here?


Our mission at CTMC is to bridge the gap between the academic research environment, state of the art cell therapy development and manufacturing technology platforms, and leaders in clinical cancer care to enable rapid advancement of novel therapeutics from concept to clinic.

Our joint venture between MD Anderson Cancer Center, the world-renowned cancer center, and Resilience, a network of advanced biopharmaceutical solutions, creates a collaboration of cancer experts and state of the art development and manufacturing technologies. This unique business model has created a biotech-like engine within the prestigious Texas Medical Center so we can bring life-saving medicines more quickly and effectively to patients.


In this new era of precision medicine, we are shaping the direction of cancer treatment by combining the best talent from biotech and academia to create a dynamic and stimulating work environment with opportunities for growth – both personally and professionally. This drive and passion to create life-changing cancer treatments for patients is at the forefront of all that we do.


If you are seeking the next challenge with the desire to contribute to our unified goal of treating patients in their battle with cancer, contact CTMC at: hr@ctmc.com

Job Openings


About CTMC 

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 

 
Responsibilities  

  • Directly manage multiple development projects, leading cross-functional teams through strategy, planning and execution of projects at the manufacturing site, and driving these projects to IND filing and first in human clinical trials.  
  • Project leadership will encompass cell therapy programs that are developed in collaboration with MDACC faculty and with biotechnology companies.  
  • Drive novel cell therapy projects through IND studies to first-in-human clinical trials; leading at least 2 programs to the clinic over the first 12 months. 
  • Coordinate development activities to assure a high-quality process and assays are ready for Manufacturing and QC on time. 
  • Oversee the transition from Development into Manufacturing and the execution of supportive engineering runs. 
  • Coordinate functional groups with Regulatory to generate pre-IND and IND submissions and those regulatory strategies are clearly communicated. 
  • Coordinate with hospital clinicians to enable a transparent exchange of clinical data 
  • Prepare and track project scope of work, project plans and budgets.  
  • Monitor project progress and ensure execution and accountability within the team. 
  • Proactively identify project issues, potential risks, and delays, and provide strategies for risk mitigation.  
  • Clearly and effectively communicate project progress and provide visibility to the project team, functional heads, senior management, and external partners.  
  • Contribute to the organizational and project governance structure: 
  • Provide visibility across projects and departments. 
  • Facilitate and support project transitions between departments to move projects from development space into the GMP environment and through IND submission. 
  • Other duties as required.               

Qualifications/Skills 

  • Bachelor’s or Master’s degree in engineering, science, or related field required, PhD preferred. 
  • 9+ yr.’s. of relevant work experience, including 5 years of project leadership/ management in cell therapy or closely related field or equivalent combination of education and experience. 
  • Demonstrate familiarity with Biologics development to IND required. 
  • Previous experience with Cell Therapy manufacturing required. 
  • Demonstrate high level of emotional intelligence and the ability to create a collaborative trusting team. 
  • Possess mindset focus on strategic thinking, data-driven decision making and effective communication. 
  • Proficient in Microsoft Outlook, Teams, Project, Excel, SharePoint, and PowerPoint. 
  • Previous experience with matrix project management and/ or agile project management is beneficial. 

Working Conditions, Equipment, Physical Demands  

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:  

Equipment- 

  • Computer 
  • Printer 
  • Telephone 

Physical Demands-  

  • Prolonged periods of sitting at a desk and working on a computer 

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.  

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.  

Apply Now

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 

Responsibilities

  • Assist with training staff on proper operations and documentation in cGMP cleanroom facilities. 
  • Operate standard cleanroom equipment: Incubators, BSCs, and Centrifuges. 
  • Operate the following Cell Therapy equipment: CliniMacs Prodigies, G-Rexes, Incubators, Cell Stacks, Cobes, or Lovos.   
  • Provide input and assistance in executing training for cleanroom personnel cGMP, best practices and awareness training related to working in a cleanroom environment. 
  • Coordinates with various departments, such as QA, QC, Material Management, Process Development, and Project Management when required to ensure deadlines are met. 
  • Establish a culture of continuous improvement, collaborative spirit, and dedication to safe workplace practices. 
  • Assist support for routine maintenance activities.  
  • Ensure transparent communication with staff, teams, support functions, and site leadership team.   
  • Establish, drive and report key performance indicators in alignment with Cell Therapy Manufacturing and Biologics Development goals. 
  • Other duties as assigned. 

Qualifications/Skills

  • B.S. preferred; or equivalent combination of education and experience.
  • Previous experience with standard cleanroom equipment: Incubators, BSCs, and Centrifuges preferred. 
  • Able to understand and follow personnel flows, cleaning procedures, gowning requirements and other procedures defining requirements necessary to ensure cGMP compliant operations of cleanroom facilities. 
  • Meticulous attention to detail in terms of documentation, following procedure SOPs, and performing functions as it pertains to the Batch Record. 
  • Able to provide input to develop new SOPs for new and incoming equipment. 
  • Proficient with Microsoft Office: Word, Excel, and Outlook.
  • Previous GMP Experience preferred.

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment-

  • Computer
  • Printer
  • Facsimile
  • Telephone
  • Manufacturing equipment

Physical Demands- 

  • Frequent standing, walking, sitting, and reaching required.
  • Frequent lifting up to 10 lbs. required.
  • Occasional lifting, pushing, and pulling up to 50 lbs. required.
  • Frequent use of computer/keyboard required.

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


Responsibilities

  • Manage the day-to-day assignments of storeroom and offsite warehouse job tasks and monitor completion of required activities.
  • Manage the day-to-day assignments of storeroom and offsite warehouse job tasks and monitor completion of required activities.
  • Receive incoming shipments of non-GMP/GMP materials and equipment following established procedures.
  • Dispense and kit GMP materials to support production operations.
  • Submit and follow up on replenishment requisitions for GMP materials. 
  • Maintain accurate inventory of GMP materials by performing accurate dispensing transactions.  
  • Perform, schedule, and verify inventory cycle counts. 
  • Perform accurate ERP and manual inventory transactions.  
  • Track and ensure completion of team projects.
  • Handle final and incoming product shipments. 
  • Monitor Kanban area to ensure adequate replenishment of materials. 
  • Communicate inventory discrepancies to supervisor and escalate as necessary. 
  • Capable of Cross-training in all areas of the warehouse operations (ie. Receiving, Inventory Management, Kitting, Shipping).
  • Pick, Pack, and Ship finished product, materials, and equipment as required per established policies and procedures. 
  • Ensure individual employee training is up to date.  
  • Adhere to safety and GMP procedures and requirements at all times. 
  • Other duties as assigned.

Qualifications/Skills

  • High School Diploma or equivalent.
  • 2+ yr.’s of industry related experience required, preferably in biotech manufacturing.
  • Proficient with MS Office (Excel, Outlook, etc.).

Working Conditions, Equipment, Physical Demands

Equipment- Computer, printer, Fax, Telephone, Manufacturing equipment

Physical Demands-  

  • Frequent standing, walking, sitting, and reaching required.
  • Frequent lifting up to 10 lbs. required.
  • Occasional lifting, pushing, and pulling up to 50 lbs. required.
  • Frequent use of computer/keyboard required.

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


Responsibilities

  • Execute assays in accordance with established protocols and SOPs.
  • Perform experiments to identify and reduce sources of assay error in repeated use and among multiple users.
  • Participate in assay qualification, validation, and transfer activities.
  • Maintain accurate and timely experimental records.
  • Observe applicable safety and security procedures.
  • Assist in data entry and review for analysis and trending.
  • Monitor inventory of supplies and order supplies as needed.
  • Assist in organizing and monitoring of sample inventory.
  • Perform routine maintenance, calibration, and quality control of AD equipmen.t
  • Maintain knowledge of regulatory standards for analytical testing of cell therapy products.
  • Other duties as assigned.

Qualifications/Skills

  • Bachelor’s degree in a related field required.
  • 2+ yr.’s of industry related experience required, preferably in biotech manufacturing.
  • Strong hands-on experience with the following techniques is highly preferred:
    • Mammalian cell culture and aseptic techniques.
    • Nucleic acid extraction and quantitation.
    • PCR, qPCR, or ddPCR assays to quantify nucleic acid abundance.
    • Flow cytometry sample preparation, data acquisition, and analysis
    • ELISA assays to quantify protein abundance.
    • Handling of viral vectors, in particular retroviral and lentiviral vectors.
  • Proficient with MS Office (Excel, Outlook, etc.).

Working Conditions, Equipment, Physical Demands

Equipment-

Computer, printer, fax, telephone, and laboratory testing equipment

Physical Demands-
  • Occasional standing, walking required

  • Frequent sitting, reaching, and computer/keyboard usage

  • Occasional lifting, pushing, and pulling up to 10 lbs. required

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


Responsibilities

  • Follows personnel flows, cleaning procedures, gowning requirements and other procedures defining requirements necessary to ensure cGMP compliant operations of cleanroom facilities. 
  • Assists with training staff on proper operations and documentation in cGMP cleanroom facilities. 
  • Performs or assists in deviation writing, CAPAs, Root Cause Analysis, or Change Controls. Technical writing skills are required. 
  • Uses standard cleanroom equipment: Incubators, BSCs, and Centrifuges. 
  • Uses the following Cell Therapy equipment: CliniMacs Prodigies, G-Rexes, Waves/Xuris, Incubators, Cell Stacks, Cobes, or Lovos.   
  • Provides input and assistance in executing training for cleanroom personnel cGMP, best practices and awareness training related to working in a cleanroom environment 
  • Coordinates with various departments, such as QA, QC, Material Management, Process Development, and Project Management when required to ensure deadlines are met. 
  • Establishes a culture of continuous improvement, collaborative spirit, and dedication to safe workplace practices. 
  • Creates new SOPs for new and incoming equipment. 
  • Assists support for routine maintenance activities.  
  • Ensures transparent communication with staff, teams, support functions, and site leadership team.   
  • Establishes, drives and reports key performance indicators in alignment with Cell Therapy Manufacturing and Biologics Development goals. 
  • Other duties as assigned. 

Qualifications/Skills

  • Bachelor’s degree or equivalent required.
  • 5+ yr.’s experience in a related manufacturing environment (cell therapy or biotech) required.
  • Previous experience with standard cleanroom equipment: Incubators, BSCs, and Centrifuges preferred. 
  • Previous experience with the following Cell Therapy equipment: CliniMacs Prodigies, G-Rexes, Waves/Xuris, Incubators, Cell Stacks, Cobes, or Lovos preferred.
  • Meticulous attention to detail required in terms of documentation, following procedural SOPs, and performing functions as it pertains to the Batch Record. 
  • Proficient with Microsoft Office: Word, Excel, and Outlook.
  • Previous GMP Experience required.

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment-

  • Computer
  • Printer
  • Facsimile
  • Telephone
  • Manufacturing equipment

Physical Demands-  

  • Frequent standing, walking, sitting, and reaching required.
  • Frequent lifting up to 10 lbs. required.
  • Occasional lifting, pushing, and pulling up to 50 lbs. required.
  • Frequent use of computer/keyboard required.

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


Responsibilities

  • Manages the accounts payable process including adherence to the internal purchase orders process and ensuring proper support documentation is included all POs and invoices.
  • Manages the accounts receivable process including preparing, posting, verifying, and recording customer payments and transactions related to accounts receivable.
  • Creates invoices according to company practices; submits invoices to customers.
  • Maintains and updates customer files.
  • Performs and/or assist with monthly, quarterly, and annual accounting and closing activities including reconciliations of bank and credit card accounts.
  • Prepares, reviews, and analyzes flux balance sheet and P&L analysis, general ledger activity, contracts, and other analysis as required.
  • Assists with annual audits, creates financial reports/support as necessary, including internal/external reporting requirements.
  • Prepares journal entries as appropriate to ensure general ledger is in conformance with GAAP.

Qualifications/Skills

  • Bachelor’s Degree in accounting or finance required.
  • 2+ yr.’s experience in accounting preferred.
  • Thorough understanding of GAAP; strong research skills.
  • Experience with handling day-to-day accounts payable and accounts receivable process.
  • Previous experience with monthly, quarterly, annual, and external accounting and reporting responsibilities.
  • Strong attention to detail and adherence to reporting deadlines.
  • Previous experience with accounting software and Microsoft Office (Excel, Outlook, etc.)

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment-

  • Computer
  • Printer
  • Facsimile
  • Telephone

Physical Demands-  

  • Prolonged periods of sitting at a desk and working on a computer 

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


Responsibilities

  • Works specifically on the development of product characterization assays and help establish correlations between clinical outcomes and product/process characteristics of ex vivo T-cell therapeutics.
  • Identify key metrics to help further characterize therapeutic products and identify potential Critical Quality Attributes (CQAs).
  • Develop, optimize, and pre-qualify (if needed) analytical methods in various platforms including, flow cytometry, ELISA, qPCR and/or ddPCR.
  • Work closely with process development, apply developed methods to inform in-process characterization (phenotypic and functional) of gene edited cells.
  • Collect and interpret data, prepare development reports, and present results to cross functional project team to provide updates on project status/ progress.
  • Support the development of standard operating procedures, test methods and associated forms, batch records, analytical descriptions and sampling plans. Act as subject matter expert in the training and transfer of analytical test methods to internal and external collaborators.
  • Act as SME in the training and transfer of analytical test methods to internal and external collaborators.
  • Adhere to organizational safety, environmental and industrial hygiene procedures and practices, and actively participate in maintaining and enhancing the safety of the workplace and the laboratories.
  • Apply organizational and creative skills to improve lab operations and workflow efficiencies.
  • Other duties as required.

Qualifications/Skills

  • Bachelor’s degree in a related field required, Ph.D. in a related scientific/engineering field preferred.
  • 10+ yr.’s of relevant experience in biotech or contract testing organization; or combination of education and experience.
  • Experience in Analytical Development or Quality Control, particularly as related to T cell therapies.
  • Understanding of the FDA Regulatory requirements as related to cellular identity, purity, and potency.
  • Required: Expertise and hands-on experience in the development of multi-parameter flow cytometry assays for the characterization of cell therapy products.
  • Experience in developing other analytical methods for cell therapy products, e.g., cell-based functional assays, q-PCR/ddPCR assays, is a plus.
  • Strong scientific understanding of the fundamental principles of immuno-oncology.
  • Based on scientific understanding of the process, applies GMP requirements to analytical method development, clinical manufacturing, and process/assay transfer activities.
  • Demonstrated ability to collaborate effectively in a multi-disciplinary team.
  • Demonstrated strong communication skills, interpersonal skills, and a superior drive for results.
  • Excellent written, oral, interpersonal and presentation skills and the ability to effectively interface with senior management and staff.
  • Excellent judgment and creative problem-solving skills, including negotiation and conflict resolution skills.
  • Ability to operate as an effective tactical, as well as strategic thinker.
  • Ability to coach and influence junior level scientists and associates.

Working Conditions, Equipment, Physical Demands

Equipment-

Computer, printer, fax, telephone, and laboratory testing equipment

Physical Demands-

  • Occasional standing, walking required
  • Frequent sitting, reaching, and computer/keyboard usage
  • Occasional lifting, pushing, and pulling up to 10 lbs. required

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now