Why Work Here?


Our mission at CTMC is to bridge the gap between the academic research environment, state of the art cell therapy development and manufacturing technology platforms, and leaders in clinical cancer care to enable rapid advancement of novel therapeutics from concept to clinic.

Our joint venture between MD Anderson Cancer Center, the world-renowned cancer center, and Resilience, a network of advanced biopharmaceutical solutions, creates a collaboration of cancer experts and state of the art development and manufacturing technologies. This unique business model has created a biotech-like engine within the prestigious Texas Medical Center so we can bring life-saving medicines more quickly and effectively to patients.


In this new era of precision medicine, we are shaping the direction of cancer treatment by combining the best talent from biotech and academia to create a dynamic and stimulating work environment with opportunities for growth – both personally and professionally. This drive and passion to create life-changing cancer treatments for patients is at the forefront of all that we do.


If you are seeking the next challenge with the desire to contribute to our unified goal of treating patients in their battle with cancer, contact CTMC at: hr@ctmc.com

Job Openings


About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


Responsibilities

CTMC is looking for a highly motivated Project Leader with exceptional scientific and communication skills to support our Houston, TX development and manufacturing site. This position will be responsible for managing execution of cell therapy projects including cross-functional planning and execution, aligning scientific and therapeutic strategy, early phase development, CMC, and regulatory filing to enable accelerated FDA approval and patient access to life saving therapies. Prior experience leading and managing complex and cross-functional projects is required, and a strong understanding of CMC and drug development is preferred. This role will report to the Head of Project and Alliance Leadership.

  • Directly manage multiple development projects, leading cross-functional teams through strategy, planning and execution of projects, and driving these projects to IND filing and first in human clinical trials.
    • Project leadership will encompass cell therapy programs that are developed in collaboration with MDACC faculty and with biotechnology companies.
    • Drive novel cell therapy projects through IND studies to first-in-human clinical trials; leading at least 2 programs to the clinic over the first 12 months.
    • Coordinate development activities to assure a high-quality process and assays are ready for Manufacturing and QC on time.
    • Oversee the transition from Development into Manufacturing and the execution of supportive engineering runs.
    • Coordinate functional groups with Regulatory to generate pre-IND and IND submissions and those regulatory strategies are clearly communicated.
    • Manage the alliance with partners developing innovative, curative cell therapies. Use scientific knowledge and thinking to propel projects through execution.
  • Prepare, track and report project scope of work, project plans and budgets.
  • Monitor project progress and ensure execution and accountability within the team.
  • Proactively identify project issues, potential risks, and delays, and provide strategies for risk mitigation.
  • Clearly and effectively communicate project progress and provide visibility to the project team, functional heads, senior management, and external partners.
  • Contribute to the organizational and project governance structure:
    • Provide visibility across projects and departments.
    • Facilitate and support project transitions between departments to move projects from development space into the GMP environment and through IND submission.
  • Other duties as required            

Qualifications/Skills

  • Bachelor’s degree or Master’s in engineering, science, or related field required, PhD preferred.
  • 12+ yr.’s. of relevant work experience, including 6 years of project leadership/ management in cell therapy or closely related field or equivalent combination of education and experience.
  • Demonstrate familiarity with Biologics development to IND, required.
  • Previous experience with Cell Therapy manufacturing preferred.
  • High-level of communication skills required, both written and verbal.
  • Demonstrate organization, focus and diplomacy skills.
  • Demonstrate high level of emotional intelligence and the ability to create a collaborative trusting team.
  • Possess mindset focus on strategic thinking, data-driven decision making and effective communication.
  • Proficient in Microsoft Outlook, Teams, Project, Excel, SharePoint, and PowerPoint.
  • Previous experience with matrix project management and/ or agile project management is beneficial.
  • Ability to work onsite as needed (remote candidates will be considered with some travel required 25% of the time), relocation preferred.

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment-

  • Computer
  • Printer
  • Telephone

Physical Demands-

  • Prolonged periods of sitting at a desk and working on a computer

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


Responsibilities

  • Perform cleaning, documentation, processing, and materials procurement for the manufacturing department.
  • Assist with training staff on proper operations and documentation in cGMP cleanroom facilities. 
  • Operate standard cleanroom equipment: Incubators, BSCs, and Centrifuges. 
  • Operate the following Cell Therapy equipment: CliniMacs Prodigies, G-Rexes, Incubators, Cell Stacks, Cobes, or Lovos.   
  • Develop SOPs for new and incoming equipment.
  • Provide input and assistance in executing training for cleanroom personnel cGMP, best practices and awareness training related to working in a cleanroom environment. 
  • Coordinates with various departments, such as QA, QC, Material Management, Process Development, and Project Management when required to ensure deadlines are met. 
  • Establish a culture of continuous improvement, collaborative spirit, and dedication to safe workplace practices. 
  • Assist support for routine maintenance activities when needed.  
  • Ensure transparent communication with staff, teams, support functions, and site leadership team.   
  • Establish, drive and report key performance indicators in alignment with Cell Therapy Manufacturing and Biologics Development goals. 
  • Other duties as assigned. 

Qualifications/Skills

  • B.S. preferred, or equivalent education and experience.
  • 2+ yr.’s experience with standard cleanroom equipment: Incubators, BSCs, and Centrifuges required.
  • Previous experience with the following Cell Therapy equipment: CliniMacs Prodigies, G-Rexes, Incubators, Cell Stacks, Cobes, or Lovos preferred.
  • Previous experience with technical writing required.
  • Able to understand and follow personnel flows, cleaning procedures, gowning requirements and other procedures defining requirements necessary to ensure cGMP compliant operations of cleanroom facilities. 
  • Meticulous attention to detail in terms of documentation, following procedure SOPs, and performing functions as it pertains to the Batch Record. 
  • Previous experience with manufacturing calculations and conversions using mathematics and critical thinking preferred or ability to learn.
  • Able to provide input to develop new SOPs for new and incoming equipment. 
  • Proficient with Microsoft Office: Word, Excel, and Outlook.
  • Previous GMP Experience preferred.
  • Ability to work a flexible schedule based off business needs.

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment-

  • Computer
  • Printer
  • Facsimile
  • Telephone
  • Manufacturing equipment

Physical Demands-  

  • Frequent standing, walking, sitting, and reaching required.
  • Frequent lifting up to 10 lbs. required.
  • Occasional lifting, pushing, and pulling up to 50 lbs. required.
  • Frequent use of computer/keyboard required.

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now

About CTMC

   CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


 Responsibilities

  • Execute experiments to develop, optimize, and standardize viral vector production processes in accordance with established protocols.
  • Execute experiments to develop and characterize clonal cell lines for viral vector production in accordance with established protocols.
  • Routine maintenance of adherent and suspension mammalian cell lines for process and analytical development work.
  • Participate in process demonstration, training, and transfer activities.
  • Maintain accurate and timely experimental records.
  • Assist in data entry and review for analysis and trending.
  • Monitor inventory of laboratory supplies and samples; order supplies as needed.
  • Perform routine maintenance, calibration, and quality control of process and analytical development equipment.
  • Adhere to organizational safety, environmental, and industrial hygiene practices; actively participate in maintaining and enhancing workplace safety.
  • Apply organizational and creative skills to improve lab operations and workflow efficiency.
  • Other duties as assigned.

Qualifications/Skills

  • Bachelor’s degree in a related field required.
  • 2+ yr.’s of industry related experience required, preferably in biotech product development or manufacturing or equivalent combination of education and experience.
  • Strong hands-on experience with the following techniques is highly desired: 
    1. Mammalian cell culture and aseptic techniques.
    2. Handling of viral vectors, in particular gamma-retroviral and/or lentiviral vectors.
    3. Adherent and suspension cell culture at lab scale and pilot scale (up to 10L) using manual culture systems (T flasks and multi-layer cell factories).
    4. Clonal cell line maintenance and banking.
  • Familiarity with the following techniques is a plus:
    1. Transient transfection of DNA at lab scale and pilot scale (up to 10L).
    2. Downstream processing of viral vectors using ion-exchange chromatography, direct flow filtration, and tangential flow filtration.
    3. Methods for viral vector titer and purity analysis using cell-based, flow cytometry, qPCR/ddPCR, and ELISA methods.
    4. Methods for cell line characterization using flow cytometry and qPCR/ddPCR methods.
  • Proficient with MS Office (Excel, Outlook, etc.).

Working Conditions, Equipment, Physical Demands 

The incumbent in this position works in an office and laboratory environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment- Computer, printer, facsimile, telephone, laboratory equipment

Physical Demands- 

  • Occasional standing and walking required
  • Frequent sitting, reaching, and computer/keyboard usage
  • Occasional lifting, pushing, and pulling up to 10 lbs. required

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act. 

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary. 

Apply Now

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 


Responsibilities

  • Perform all activities related to incoming equipment including inspection, documentation, hands-on handling, and oversight of the delivery of all cell therapy and viral vector equipment.
  • Perform functionality checks on equipment and evaluate repair and/or replacement needs.
  • Perform routine maintenance on select equipment.
  • Assist in drafting and approving of all Standard Operating Procedures for commonly utilized equipment in cell therapy clean rooms, quality control labs, process development laboratories (examples COBE 2991, CliniMACS Prodigy, and Lovo).
  • Track all equipment SOPs within the QMS system for timely approval.
  • Assist in the set-up of the on-boarding process for new, incoming personnel.
  • Assist in the management of the badge access system at CTMC.
  • Manage the Maximo/CMMS program: input tickets, pull work orders, etc.
  • Obtain quotes and review service agreements for new equipment.
  • Assist in the review or drafting of all Change Controls, IQOQs, or validation packets for all GMP equipment.
  • Assist in the training of any CTMC associates for new equipment.
  • Plan, coordinate, and execute between CTMC staff and outside vendors to ensure operations are performed for maximal efficiency.
  • Ensure the timely updates of any spreadsheets or database systems used to track preventive maintenance equipment.
  • Ensure all compliance requirements are met and up to date on all GMP Equipment.
  • Other duties as assigned.

Qualifications/Skills

  • Bachelor’s degree in relevant field or equivalent combination of education and experience.
  • 3+ yr.’s experience with handling and maintenance of manufacturing and laboratory equipment in biotech or cell therapy environment.
  • 2+ yr.’s GMP Experience preferred, previous experience with GMP required.
  • Previous experience working in biotech manufacturing with equipment preferred.
  • Previous experience working with service agreements for equipment preferred.
  • Good communication skills and ability to explain equipment concerns.
  • Able to work independently with minimal supervision.
  • Able to trouble-shoot and diagnose equipment issues.

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office and laboratory environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment-

  • Computer
  • Printer
  • Facsimile
  • Telephone
  • Manufacturing Equipment

Physical Demands-  

  • Frequent standing, walking, sitting, and reaching required.
  • Frequent lifting up to 10 lbs. required.
  • Occasional lifting, pushing, and pulling up to 50 lbs. required.
  • Frequent use of computer/keyboard required.

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

Apply Now