Why Work Here?

About CTMC

     CTMC (Cell Therapy Manufacturing Center), a joint venture between Resilience and MD Anderson Cancer Center, is a first-of-its-kind biotech located in the world-renowned Texas Medical Center created to accelerate cell therapies moving from research to patients. CTMC develops and manufactures cell therapies invented at MD Anderson, as well as biotechs, including a variety of modalities such as CAR-T, TIL, ETC and TCR-T.  We aim to file 4 INDs in the first 12 months as we work closely with MDACC research and clinical faculty to bring impactful cell therapies to cancer patients. Our partnership with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in their first two years gives CTMC access to advanced technology and processes and enables us to stay at the cutting edge of biomanufacturing practices. Through the capabilities within CTMC and our alliance with MD Anderson Cancer Center and National Resilience, we co-develop cell therapy products with biotech companies and help them industrialize and accelerate their innovative therapeutics to reach the clinic quicker and ultimately maximize patient impact.    

     CTMC is housed in a state-of-the-art 60,000sqft development and manufacturing facility in the Texas Medical Center with an integrated team of 75 industry veterans and scientists with a depth of cell therapy expertise.  The unique structure of our joint venture with two highly established partners gives the organization financial stability and a long-term horizon, despite the current environment of funding uncertainty in the biotech field.  Our broad scope and novel corporate structure allow employees a plethora of development opportunities for members of our team.  We are passionate about aggressively bringing life-saving cures to patients and achieving it through a cohesive team-first culture and balanced work-life environment for our staff.  If you feel you can contribute to our mission and be part of a newly imagined biotech, we welcome your application. 

Responsibilities

• Perform cleaning, documentation, processing, and materials procurement for the manufacturing department.
• Assist with training staff on proper operations and documentation in cGMP cleanroom facilities. 
• Operate standard cleanroom equipment: Incubators, BSCs, and Centrifuges. 
• Operate the following Cell Therapy equipment: CliniMacs Prodigies, G-Rexes, Incubators, Cell Stacks, Cobes, or Lovos.   
• Develop SOPs for new and incoming equipment.
• Provide input and assistance in executing training for cleanroom personnel cGMP, best practices and awareness training related to working in a cleanroom environment. 
• Coordinates with various departments, such as QA, QC, Material Management, Process Development, and Project Management when required to ensure deadlines are met. 
• Establish a culture of continuous improvement, collaborative spirit, and dedication to safe workplace practices. 
• Assist support for routine maintenance activities when needed.  
• Ensure transparent communication with staff, teams, support functions, and site leadership team.   
• Establish, drive and report key performance indicators in alignment with Cell Therapy Manufacturing and Biologics Development goals. 
• Other duties as assigned. 

Qualifications/Skills

• B.S. preferred, or equivalent education and experience.
• 2+ yr.’s experience with standard cleanroom equipment: Incubators, BSCs, and Centrifuges required.
• Previous experience with the following Cell Therapy equipment: CliniMacs Prodigies, G-Rexes, Incubators, Cell Stacks, Cobes, or Lovos preferred.
• Previous experience with technical writing required.
• Able to understand and follow personnel flows, cleaning procedures, gowning requirements and other procedures defining requirements necessary to ensure cGMP compliant operations of cleanroom facilities. 
• Meticulous attention to detail in terms of documentation, following procedure SOPs, and performing functions as it pertains to the Batch Record. 
• Previous experience with manufacturing calculations and conversions using mathematics and critical thinking preferred or ability to learn.
• Able to provide input to develop new SOPs for new and incoming equipment. 
• Proficient with Microsoft Office: Word, Excel, and Outlook.
• Previous GMP Experience preferred.
• Ability to work a flexible schedule based off business needs.

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment-

• Computer
• Printer
• Facsimile
• Telephone
• Manufacturing equipment

Physical Demands-  

• Frequent standing, walking, sitting, and reaching required.
• Frequent lifting up to 10 lbs. required.
• Occasional lifting, pushing, and pulling up to 50 lbs. required.
• Frequent use of computer/keyboard required.

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

About CTMC

CTMC is a pioneering biotech joint venture, formed by National Resilience and MD Anderson Cancer Center, and located in the renowned Texas Medical Center. Our mission is to accelerate cell therapies from bench to bedside. We offer a wide range of cell therapy modalities, including CAR-T, TIL, ETC, and TCR-T. Our expert team collaborates closely with MD Anderson’s research and clinical faculty, bringing impactful cell therapies to cancer patients.

In our first year alone, we have filed four INDs, each ahead of schedule, demonstrating our commitment to delivering innovative treatments to patients with speed and precision. Our alliance with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in two years, enables us to remain at the forefront of biomanufacturing practices, leveraging advanced technology and processes to deliver exceptional results.

Our state-of-the-art, 60,000 sq. ft. facility in the Texas Medical Center is staffed by an integrated team of 75 industry veterans and scientists who are passionate about bringing life-saving cures to patients. Our unique joint venture structure, with two highly established partners, provides us with the financial stability and long-term horizon to achieve our mission.

At CTMC, we value our employees and offer a variety of development opportunities within our novel corporate structure. We foster a team-first culture and a balanced work-life environment to ensure our staff is energized and engaged in our mission. If you share our passion for advancing the frontiers of medical science with innovative therapeutics and want to join a highly dedicated team committed to delivering novel cures to patients, we invite you to submit your application. We look forward to hearing from you and exploring how your skills and expertise can help us achieve our mission.

Responsibilities

• Develop efficient Quality Systems and Operations to compliantly support cell therapy and viral vector manufacturing as a core competency for the Organization.  Autologous cell therapies are a powerful new modality that holds the potential to cure cancer; however, they present challenges in the manufacture and Quality oversight due to the time pressure to release batches.  Thus, the overall focus for this Leader is to develop a comprehensive, compliant and fit-for-purpose Quality system overarching internal development and GMP manufacturing and testing. 
  • Further developing an established comprehensive Quality system, including materials controls; production systems; facilities, equipment and environmental validation and maintenance; internal/external audit program; deviation/CAPA; training; change control; and document control.  We released 50 batches last year, are targeting 100 this year and more in the coming years.  The Quality systems must scale with our expanding Operations.  
  • Implement Veeva QMS to integrate with existing Veeva QualityDocs and RIMS implementation and support implementation of additional electronic systems including LIMS, ERP and EM.
  • Interact with Manufacturing, Development, QC, Regulatory and Project Management to actively support the Quality aspects of Project Development from preclinical through IND to clinical.
  • Develop approaches with all groups to increase our compliance and productivity.  When done well compliance can enhance productivity and help find ways to reduce time spent on non-value-added activities and focus on the value-creating ones         
• External Partner Relations:  We work on partnered projects with both academic and biotech organizations.  Our overall approach to Quality remains the same.  We structure interactions with outside groups such that they have visibility into our operations, but that they don’t have formal oversite responsibilities (i.e., signing off on batch records or batch release).  This distinction (from being a CMO) is critical to maintaining our independence and efficiency.  The leader of this group will be responsible for interacting with outside Quality groups from our partners and providing such structure through formal Quality Agreements, but more so through establishing trusting relationships through displaying competency, compliance, and transparency.  
• Design the Quality organization by positioning the current staff for success, while identifying gaps and recruiting key talent.  The QA group currently has 10 team members and is expected to potentially increase over the next year.  Create an organizational structure that is fit-for-purpose, allows talent development and cross-training and is robust.  Promote a Quality Culture across the organization where compliance complements rigorous, science-based product development and manufacturing.  
• Other duties as required.           

Qualifications/Skills

• BS/MS in scientific field with 12+ years of experience in Quality of Biologics, cell therapy preferred, or equivalent combination of education & experience.
• 6+ yrs.+ in an upper-level management role leading a team, preferably in quality assurance.
• Balance an independent, compliant mindset to protect patient safety with our Mission to cure cancer in patients who have no other treatment options. 
• Leadership capabilities to define, populate, manage, and develop a team. 
• Demonstrated ability to collaborate effectively in a multi-disciplinary team. 
• Demonstrated strong communication skills, interpersonal skills, and a superior drive for results. 
• Excellent written, oral, interpersonal and presentation skills and the ability to effectively interface with senior management, staff and outside organizations. 
• Excellent judgment and creative problem-solving skills, including negotiation and conflict resolution skills.  
• Ability to operate as an effective tactical, as well as strategic thinker. 
• Expected to be full-time, on-site.

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment- Computer, printer, fax, and telephone.

Physical Demands- Prolonged periods of sitting at a desk and working on a computer and must be able to lift up to 15 pounds at times. In addition, ability to sterile-gown and perform activities in the manufacturing suite as well as raw material area when applicable.

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

About CTMC 

CTMC is a pioneering biotech joint venture, formed by National Resilience and MD Anderson Cancer Center, and located in the renowned Texas Medical Center. Our mission is to accelerate cell therapies from bench to bedside. We offer a wide range of cell therapy modalities, including CAR-T, TIL, ETC, and TCR-T. Our expert team collaborates closely with MD Anderson’s research and clinical faculty, bringing impactful cell therapies to cancer patients. 

In our first year alone, we have filed four INDs, each ahead of schedule, demonstrating our commitment to delivering innovative treatments to patients with speed and precision. Our alliance with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in two years, enables us to remain at the forefront of biomanufacturing practices, leveraging advanced technology and processes to deliver exceptional results. 

Our state-of-the-art, 60,000 sq. ft. facility in the Texas Medical Center is staffed by an integrated team of 75 industry veterans and scientists who are passionate about bringing life-saving cures to patients. Our unique joint venture structure, with two highly established partners, provides us with the financial stability and long-term horizon to achieve our mission. 

At CTMC, we value our employees and offer a variety of development opportunities within our novel corporate structure. We foster a team-first culture and a balanced work-life environment to ensure our staff is energized and engaged in our mission. If you share our passion for advancing the frontiers of medical science with innovative therapeutics and want to join a highly dedicated team committed to delivering novel cures to patients, we invite you to submit your application. We look forward to hearing from you and exploring how your skills and expertise can help us achieve our mission.

 Responsibilities

• Learn and observe the execution of different state-of-the-art cell based or molecular biology techniques which are typically used in the development of cell therapies.  
• Maintains cultures of primary T cells and cancer cell lines with proper documentation.  
• Performs T cell-based assays such as IFNg ELISA. 
• Performs genomic DNA extractions to support molecular assays. 
• Support management of assay reagent inventory as well as other support tasks laid out by their supervisor. 
• Participates in lab meetings and other collaborative activities.  
• Showcases achievements/learnings with a presentation at the conclusion of internship to the broader development team. 
• Other duties as required. 

Qualifications/Skills

• High School Diploma required; enrollment in a minimum Bachelor’s degree program in a relevant field preferred.
• Previous laboratory experience preferred.
• Able to learn testing procedures and work utilizing standard operating procedures.
• Able to work in a fast-paced environment.
• Demonstrated ability to be nimble, collaborative, and eager to contribute.
• Good communication skills.
• Proficient with MS Office (Excel, Outlook, etc.).

 *Internship is from May-August (10-12 weeks with flexibility on start and end date)

Working Conditions, Equipment, Physical Demands 

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands: 

Equipment-

• Computer, printer, fax, telephone, and laboratory testing equipment

Physical Demands- 

• Occasional standing and walking required
• Frequent sitting, reaching, and computer/keyboard usage
• Occasional lifting, pushing, and pulling up to 10 lbs. required

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act. 

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary. 

About CTMC

CTMC is a pioneering biotech joint venture, formed by National Resilience and MD Anderson Cancer Center, and located in the renowned Texas Medical Center. Our mission is to accelerate cell therapies from bench to bedside. We offer a wide range of cell therapy modalities, including CAR-T, TIL, ETC, and TCR-T. Our expert team collaborates closely with MD Anderson’s research and clinical faculty, bringing impactful cell therapies to cancer patients. 

In our first year alone, we have filed four INDs, each ahead of schedule, demonstrating our commitment to delivering innovative treatments to patients with speed and precision. Our alliance with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in two years, enables us to remain at the forefront of biomanufacturing practices, leveraging advanced technology and processes to deliver exceptional results. 

Our state-of-the-art, 60,000 sq. ft. facility in the Texas Medical Center is staffed by an integrated team of 75 industry veterans and scientists who are passionate about bringing life-saving cures to patients. Our unique joint venture structure, with two highly established partners, provides us with the financial stability and long-term horizon to achieve our mission. 

At CTMC, we value our employees and offer a variety of development opportunities within our novel corporate structure. We foster a team-first culture and a balanced work-life environment to ensure our staff is energized and engaged in our mission. If you share our passion for advancing the frontiers of medical science with innovative therapeutics and want to join a highly dedicated team committed to delivering novel cures to patients, we invite you to submit your application. We look forward to hearing from you and exploring how your skills and expertise can help us achieve our mission.

 Responsibilities

• Record handwritten entries in facility documents.
• Input data into department spreadsheets.
• Record dates and times of cleaning activities into real-time logs.
• Escort vendors or contractors into specified clean room or lab areas.
• Check and verify safety showers and eye wash stations.
• Perform monthly fire extinguisher training.
• Shadow other facilities team members conducting various daily activities.
• Other duties as required.

Qualifications/Skills

• High School Diploma required; enrollment in a minimum Bachelor’s degree program in a relevant field preferred.
• Previous clean room experience preferred.
• Previous engineering, facility or equipment experience preferred.
• Familiarity in pharmaceuticals, bio-research, semiconductor, medical device, biologics or cell therapy manufacturing facilities preferred.
• Able to read and understand all applicable assigned standard operating procedures and policies.
• Able to understand basic mathematical concepts such as filtration rates, door pressures, or air changes.
• Able to work in a fast-paced environment.
• Demonstrated ability to be nimble, collaborative, and eager to contribute.
• Good communication skills.
• Proficient with MS Office (Excel, Outlook, etc.).
• Able to lift up to 40 lbs., work overhead and stand for extended periods of time.

  *Internship is from May-August (10-12 weeks with flexibility on start and end date)

Working Conditions, Equipment, Physical Demands 

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment- Computer, printer, fax, telephone, and laboratory testing equipment

Physical Demands- 

• Frequent standing and walking required
• Frequent sitting, reaching, and computer/keyboard usage
• Occasional lifting, pushing, and pulling up to 40 lbs. required

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act. 

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary. 

About CTMC

CTMC is a pioneering biotech joint venture, formed by National Resilience and MD Anderson Cancer Center, and located in the renowned Texas Medical Center. Our mission is to accelerate cell therapies from bench to bedside. We offer a wide range of cell therapy modalities, including CAR-T, TIL, ETC, and TCR-T. Our expert team collaborates closely with MD Anderson’s research and clinical faculty, bringing impactful cell therapies to cancer patients.

In our first year alone, we have filed four INDs, each ahead of schedule, demonstrating our commitment to delivering innovative treatments to patients with speed and precision. Our alliance with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in two years, enables us to remain at the forefront of biomanufacturing practices, leveraging advanced technology and processes to deliver exceptional results.

Our state-of-the-art, 60,000 sq. ft. facility in the Texas Medical Center is staffed by an integrated team of 75 industry veterans and scientists who are passionate about bringing life-saving cures to patients. Our unique joint venture structure, with two highly established partners, provides us with the financial stability and long-term horizon to achieve our mission.

At CTMC, we value our employees and offer a variety of development opportunities within our novel corporate structure. We foster a team-first culture and a balanced work-life environment to ensure our staff is energized and engaged in our mission. If you share our passion for advancing the frontiers of medical science with innovative therapeutics and want to join a highly dedicated team committed to delivering novel cures to patients, we invite you to submit your application. We look forward to hearing from you and exploring how your skills and expertise can help us achieve our mission.

Responsibilities

Summer Internship in the PD cell therapy group: 

The PD intern will be exposed to T-cell therapy drug development in industry and learn about the different modalities and their applications. Over the course of the internship, the candidate will: 

• Observe and discuss the different T-cell expansion processes required for T-cell therapy drugs in development at CTMC with his team members. 
  • observe hands-on cell therapy process development work with mentors in the laboratory as a learning tool, and eventually participate with execution. 
  • become knowledgeable on the processes observed and be able to discuss the different approaches with the team in group meetings.  

• Become familiar with aseptic technique and perform contamination-free cell culture. 
  • training on aseptic technique after the observation phase. 
  • successfully perform processes requiring aseptic technique. 

• Train on the use of various cell processing devices and equipment 
  • train on multiple devices used in cell therapy production, including automated and semi-automated cell processing devices. 
  • following training, the candidate will be expected to be able to independently operate equipment and be able to understand the basic mechanisms of operation for the equipment. 

• Participating in advancement of project by assisting the team. 
  • post-observation phase: the candidate is expected to add value to the team by contributing to the ongoing work to the extent of their capacity.  
  • continuous learning of new skills under the team’s guidance 
  • present their work at weekly team meetings. 

• Potential to carry a small study independently and within the scope of a larger project’s activities.
  • If the candidate shows great understanding of the processes and the ability of doing autonomous works, the candidate could be given a small study to perform independently (or assisted) under the guidance of the team or the designated mentor. 

Qualifications/Skills

• High School Diploma required; enrollment in a minimum second year Bachelor’s degree program in a relevant field preferred.
• Desire to learn cell therapy development.
• Previous laboratory experience preferred.
• Able to be a great team player.
• Able to learn testing procedures and work utilizing standard operating procedures.
• Able to work in a fast-paced environment.
• Demonstrated ability to be nimble, collaborative, and eager to contribute.
• Good communication skills.
• Proficient with MS Office (Excel, Outlook, etc.).

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment- Computer, printer, fax, and laboratory equipment

Physical Demands-

• Occasional standing and walking required
• Frequent sitting, reaching, and computer/keyboard usage
• Occasional lifting, pushing, and pulling up to 10 lbs. required

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.

About CTMC

CTMC is a pioneering biotech joint venture, formed by National Resilience and MD Anderson Cancer Center, and located in the renowned Texas Medical Center. Our mission is to accelerate cell therapies from bench to bedside. We offer a wide range of cell therapy modalities, including CAR-T, TIL, ETC, and TCR-T. Our expert team collaborates closely with MD Anderson’s research and clinical faculty, bringing impactful cell therapies to cancer patients.

In our first year alone, we have filed four INDs, each ahead of schedule, demonstrating our commitment to delivering innovative treatments to patients with speed and precision. Our alliance with National Resilience, an ambitious biomanufacturing organization that has raised $2 billion in two years, enables us to remain at the forefront of biomanufacturing practices, leveraging advanced technology and processes to deliver exceptional results.

Our state-of-the-art, 60,000 sq. ft. facility in the Texas Medical Center is staffed by an integrated team of 75 industry veterans and scientists who are passionate about bringing life-saving cures to patients. Our unique joint venture structure, with two highly established partners, provides us with the financial stability and long-term horizon to achieve our mission.

At CTMC, we value our employees and offer a variety of development opportunities within our novel corporate structure. We foster a team-first culture and a balanced work-life environment to ensure our staff is energized and engaged in our mission. If you share our passion for advancing the frontiers of medical science with innovative therapeutics and want to join a highly dedicated team committed to delivering novel cures to patients, we invite you to submit your application. We look forward to hearing from you and exploring how your skills and expertise can help us achieve our mission.

Responsibilities

• Represent CTMC in outreach to potential partners (from Houston to a worldwide reach).
• Maintain excellent relationships with research community, technology-transfer offices, investors, and other key stakeholders across region.
• Exploration of external research, technologies, and programs that represent a good fit for partnering opportunities.
• Provide assistance with contract development and negotiation.
• Manage collaborations with academic partners.
• Manage projects, objectives, and timelines with communication of oversight activities to leadership.
• Align business development strategy across organization’s departments.
• Facilitate collaborative relationships across internal teams to maintain high-impact engagement and a positive work environment.
• Other duties as required.

Qualifications/Skills

• Bachelor’s degree in science, or related field required, Master’s degree or higher preferred.
• 12+ yr.’s. of relevant work experience, including 5 years of management or supervisory experience (in a team or independent contract management) or closely related field or equivalent combination of education and experience.
• Previous experience with cell therapy manufacturing preferred.
• Rapid mastery of new concepts and methods with appropriate application across multiple disciplines (business, law, and science).
• High level of emotional intelligence and the ability to create a collaborative, trusting team.
• Focus on strategic thinking, data-driven decision making and effective communication.
• Strong communication skills: both written and verbal.
• Strong presentation skills.
• Demonstrated negotiation and vendor management experience a plus.
• Advanced experience in Microsoft Outlook, Teams, Project, Excel, SharePoint, and PowerPoint.

Working Conditions, Equipment, Physical Demands

The incumbent in this position works in an office environment. The incumbent in this position will use the following equipment and shall have the following physical demands:

Equipment-

• Computer
• Printer
• Telephone

Physical Demands-

• Prolonged periods of sitting at a desk and working on a computer

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act.

The above job description is an overview of the functions and requirements for this position.  This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.